She is a member of the board of advisors of the Project Sunshine Book Club. She has served on the March of Dimes Board the board of the George Foster Peabody Awards and the board of a New York City theatrical institution, Symphony Space. She is also the author of The Revolution of Evelyn Serrano (2014). The book has been adapted as a stage play. As part of that effort, Manzano is working with General Mills and its nonprofit partner, First Book, to encourage children to read and to help children across the United States gain access to books. Her children's book No Dogs Allowed, published by Simon & Schuster Children's Publishing in 2004, is one of five books selected by the General Mills initiative 'Spoonfuls of Stories'. In 1979, the Supersisters trading card set was produced and distributed one of the cards featured Manzano's name and picture. She has written for the Peabody Award-winning children's series, Little Bill, and has written a parenting column for the Sesame Workshop web site called 'Talking Outloud'. She has performed on the New York stage, in the critically acclaimed theatre pieces The Vagina Monologues and The Exonerated.
